Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes.

ABSTRACT: Macrophages exhibit diverse effector phenotypes depending on the stimuli and their microenvironment. Classically activated macrophages are primed with interferon (IFN)γ and stimulated with pathogen-associated molecular patterns. They produce inflammatory mediators and inflammatory cytokines, such as IL-12. In the presence of immune complexes (ICs), activated macrophages have decreased IL-12 production and increased IL-10 production and presumably act as regulatory macrophages. Notch signaling has been shown to regulate the effector functions of classically activated macrophages. In this study, we investigated whether Notch signaling is active in lipopolysaccharide (LPS)-stimulated macrophages in the presence of ICs. LPS/IC stimulation increased the level of cleaved Notch1 in murine macroph

SUBMITTER: Wongchana W 

PROVIDER: S-EPMC5995379 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature