Plasma disturbance of phospholipid metabolism in major depressive disorder by integration of proteomics and metabolomics.

ABSTRACT:

Introduction

Major depressive disorder (MDD) is a highly prevalent mental disorder affecting millions of people worldwide. However, a clear causative etiology of MDD remains unknown. In this study, we aimed to identify critical protein alterations in plasma from patients with MDD and integrate our proteomics and previous metabolomics data to reveal significantly perturbed pathways in MDD. An isobaric tag for relative and absolute quantification (iTRAQ)-based quantitative proteomics approach was conducted to compare plasma protein expression between patients with depression and healthy controls (CON).

Methods

For integrative analysis, Ingenuity Pathway Analysis software was used to analyze proteomics and metabolomics data and identify potential relationships among the differe

SUBMITTER: Gui SW 

PROVIDER: S-EPMC5995410 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature