Subcellular compartmentalization of proximal Gα_q-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes.

ABSTRACT: G protein-coupled receptors that signal through Gα_q (G_q receptors), such as α₁-adrenergic receptors (α₁-ARs) or angiotensin receptors, share a common proximal signaling pathway that activates phospholipase Cβ1 (PLCβ1), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP₂) to produce inositol 1,4,5-trisphosphate (IP₃) and diacylglycerol. Despite these common proximal signaling mechanisms, G_q receptors produce distinct physiological responses, yet the mechanistic basis for this remains unclear. In the heart, G_q receptors are thought to induce myocyte hypertrophy through a mechanism termed excitation-transcription coupling, which provides a mechanistic basis for compartmentalization of calcium require

SUBMITTER: Dahl EF 

PROVIDER: S-EPMC5995527 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature