Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice.

ABSTRACT: Social behaviour is regulated by activity of host-associated microbiota across multiple species. However, the molecular mechanisms mediating this relationship remain elusive. We therefore determined the dynamic, stimulus-dependent transcriptional regulation of germ-free (GF) and GF mice colonised post weaning (exGF) in the amygdala, a brain region critically involved in regulating social interaction. In GF mice the dynamic response seen in controls was attenuated and replaced by a marked increase in expression of splicing factors and alternative exon usage in GF mice upon stimulation, which was even more pronounced in exGF mice. In conclusion, we demonstrate a molecular basis for how the host microbiome is crucial for a normal behavioural response during social interaction. Our data furthe

SUBMITTER: Stilling RM 

PROVIDER: S-EPMC5995540 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature