Resilience and amygdala function in older healthy and depressed adults.

ABSTRACT:

Background

Previous studies suggest that low emotional resilience may correspond with increased or over-active amygdala function. Complementary studies suggest that emotional resilience increases with age; older adults tend to have decreased attentional bias to negative stimuli compared to younger adults. Amygdala nuclei and related brain circuits have been linked to negative affect, and depressed patients have been demonstrated to have abnormal amygdala function.

Methods

In the current study, we correlated psychological resilience measures with amygdala function measured with resting-state arterial spin-labelled (ASL) and blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in older adults with and without depression. Specifically, we target

SUBMITTER: Leaver AM 

PROVIDER: S-EPMC5995579 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature