Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.

ABSTRACT:

Objectives

Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study built upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder.

Methods

Forty participants with bipolar I disorder and 29 healthy control participants matched for age and gender were enro

SUBMITTER: Johnson CP 

PROVIDER: S-EPMC5995598 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature