Simplifying [¹⁸F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?

ABSTRACT:

Introduction

The NMDA receptor radiotracer [¹⁸F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.

Methods

For 20 existing [¹⁸F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (V_T) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) V_T images using three shortened datasets, using the original parent plasma input functions (ppIFs).

Results

Correlations with the original ppIF-derived 90-min V_Ts increased for later interval SUVs (maximal ρ = 0.78; 80-90 min). They were strong for

SUBMITTER: McGinnity CJ 

PROVIDER: S-EPMC5995767 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature