The relative contribution of causal factors in the transition from infection to clinical chlamydial disease.

ABSTRACT: Chlamydia is a major bacterial pathogen in humans and animals globally. Yet 80% of infections never progress to clinical disease. Decades of research have generated an interconnected network linking pathogen, host, and environmental factors to disease expression, but the relative importance of these and whether they account for disease progression remains unknown. To address this, we used structural equation modeling to evaluate putative factors likely to contribute to urogenital and ocular chlamydial disease in the koala (Phascolarctos cinereus). These factors include Chlamydia detection, load, and ompA genotype; urogenital and ocular microbiomes; host sex, age, weight, body condition; breading season, time of year; location; retrovirus co-infection; and major histocompatibility complex c

SUBMITTER: Quigley BL 

PROVIDER: S-EPMC5995861 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature