Critical thresholds for intracranial pressure vary over time in non-craniectomised traumatic brain injury patients.

ABSTRACT:

Background

Intracranial pressure (ICP)- and cerebral perfusion pressure (CPP)-guided therapy is central to neurocritical care for traumatic brain injury (TBI) patients. We sought to identify time-dependent critical thresholds for mortality and unfavourable outcome for ICP and CPP in non-craniectomised TBI patients.

Methods

This is a retrospective cohort study of 355 patients with moderate-to-severe TBI who received ICP monitoring and were managed without decompressive craniectomy in a tertiary hospital neurocritical care unit. Patients were grouped in 2 × 2 tables according to survival/death or favourable/unfavourable outcomes at 6 months and serial thresholds of mean ICP and CPP, using increments of 0.1 and 0.5 mmHg respectively. Sequential chi-square analysis was performed

SUBMITTER: Nourallah B 

PROVIDER: S-EPMC5996002 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature