T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103⁺ Memory Status of CD8 T Cells in the Brain.

ABSTRACT: T cell receptor-major histocompatibility complex (TCR-MHC) affinities span a wide range in a polyclonal T cell response, yet it is undefined how affinity shapes long-term properties of CD8 T cells during chronic infection with persistent antigen. Here, we investigate how the affinity of the TCR-MHC interaction shapes the phenotype of memory CD8 T cells in the chronically Toxoplasma gondii-infected brain. We employed CD8 T cells from three lines of transnuclear (TN) mice that harbor in their endogenous loci different T cell receptors specific for the same Toxoplasma antigenic epitope ROP7. The three TN CD8 T cell clones span a wide range of affinities to MHCI-ROP7. These three CD8 T cell clones have a distinct and fixed hierarchy in terms of effector function in response to th

SUBMITTER: Sanecka A 

PROVIDER: S-EPMC5996069 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature