Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death.

ABSTRACT: The transient receptor potential (TRP) ion channel family consists of a broad variety of non-selective cation channels that integrate environmental physicochemical signals for dynamic homeostatic control. Involved in a variety of cellular physiological processes, TRP channels are fundamental to the control of the cell life cycle. TRP channels from the vanilloid (TRPV) family have been directly implicated in cell death. TRPV1 is activated by pain-inducing stimuli, including inflammatory endovanilloids and pungent exovanilloids, such as capsaicin (CAP). TRPV1 activation by high doses of CAP (>10 μM) leads to necrosis, but also exhibits apoptotic characteristics. However, CAP dose-response studies are lacking in order to determine whether CAP-induced cell death occurs preferentially via necro

SUBMITTER: Ramirez-Barrantes R 

PROVIDER: S-EPMC5996173 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature