Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium.

ABSTRACT: Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide survival advantages inside and outside the host. However, systematic studies of the evolution of specialized metabolite-coding potential across Fusarium have been scarce. Here, we apply a combination of bioinformatic approaches to identify biosynthetic gene clusters (BGCs) across publicly available genomes from Fusarium, to group them into annotated families and to study gain/loss events of BGC families throughout the history of the genus. Comparison with MIBiG reference BGCs allowed assignment of 29 gene cluster families

SUBMITTER: Hoogendoorn K 

PROVIDER: S-EPMC5996196 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature