Gut Microbiota Markers in Obese Adolescent and Adult Patients: Age-Dependent Differential Patterns.

ABSTRACT: Obesity levels, especially in children, have dramatically increased over the last few decades. Recently, several studies highlighted the involvement of gut microbiota in the pathophysiology of obesity. We investigated the composition of gut microbiota in obese adolescents and adults compared to age-matched normal weight (NW) volunteers in order to assemble age- and obesity-related microbiota profiles. The composition of gut microbiota was analyzed by 16S rRNA-based metagenomics. Ecological representations of microbial communities were computed, and univariate, multivariate, and correlation analyses performed on bacterial profiles. The prediction of metagenome functional content from 16S rRNA gene surveys was carried out. Ecological analyses revealed a dissimilarity among the subgroups, and

SUBMITTER: Del Chierico F 

PROVIDER: S-EPMC5996250 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature