A field-validated approach using surveillance and genotyping data to estimate tuberculosis attributable to recent transmission in the United States.

ABSTRACT: Tuberculosis genotyping data are frequently used to estimate the proportion of tuberculosis cases in a population that are attributable to recent transmission (RT). Multiple factors influence genotype-based estimates of RT and limit the comparison of estimates over time and across geographic units. Additionally, methods used for these estimates have not been validated against field-based epidemiologic assessments of RT. Here we describe a novel genotype-based approach to estimation of RT based on the identification of plausible-source cases, which facilitates systematic comparisons over time and across geographic areas. We compared this and other genotype-based RT estimation approaches with the gold standard of field-based assessment of RT based on epidemiologic investigation in Arkansas,

SUBMITTER: France AM 

PROVIDER: S-EPMC5996379 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature