Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks.

ABSTRACT: Alterations to transcriptional regulation are an important factor in breast cancer. Noncoding RNA, such as microRNA (miR), have very influential roles in the transcriptional regulation of genes. Transcriptional regulation can be successfully modeled and analyzed using complex network theory. Particularly, interactions between two distinct classes of biological elements, such as miR and genes, can be approached through the bipartite network formalism. Based on bipartite network properties, it is possible to identify highly influential miRs in the network, such as those that have a large number of connections indicating regulation of a large set of genes. Some miRs in a network are nonredundant, which indicates that they are solely responsible of the regulation of a particular set of genes,

SUBMITTER: de Anda-Jauregui G 

PROVIDER: S-EPMC5996465 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature