Anemia and mortality in patients with nondialysis-dependent chronic kidney disease.

ABSTRACT:

Background

A combination of safety concerns and labeling changes impacted use of erythropoiesis-stimulating agents (ESAs) in renal anemia. Data regarding contemporary utilization in pre-dialysis chronic kidney disease (CKD) are lacking.

Methods

Electronic healthcare records and medical claims data of pre-dialysis CKD patients were aggregated from a large US managed care provider (2011-13). ESA use patterns, characteristics, and outcomes of ESA-treated/untreated patients were quantified.

Results

At baseline, 109/32,308 patients (0.3%) were ESA users. Treated patients were older, had more advanced CKD (58.8% vs 5.4% with stage 4/5 vs 3) and greater prevalence of comorbid diabetes, hypertension, heart failure, and peripheral vascular disease. An additional 266 patients i

SUBMITTER: Stirnadel-Farrant HA 

PROVIDER: S-EPMC5996482 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature