Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy.

ABSTRACT:

Background

Corticosteroids are routinely utilized to alleviate edema in patients with intracranial lesions and are first-line agents to combat immune-related adverse events (irAEs) that arise with immune checkpoint blockade treatment. However, it is not known if or when corticosteroids can be administered without abrogating the efforts of immunotherapy. The purpose of this study was to evaluate the impact of dexamethasone on lymphocyte activation and proliferation during checkpoint blockade to provide guidance for corticosteroid use while immunotherapy is being implemented as a cancer treatment.

Methods

Lymphocyte proliferation, differentiation, and cytokine production were evaluated during dexamethasone exposure. Human T cells were stimulated through CD3 ligation and co-sti

SUBMITTER: Giles AJ 

PROVIDER: S-EPMC5996496 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature