Wnt/β-catenin signalling is necessary for gut differentiation in a marine annelid, Platynereis dumerilii.

ABSTRACT:

Background

Wnt/β-catenin (or canonical) signalling pathway activity is necessary and used independently several times for specification of vegetal fate and endoderm, gut differentiation, maintenance of epithelium in adult intestine and the development of gut-derived organs in various vertebrate and non-vertebrate organisms. However, its conservation in later stages of digestive tract development still remains questionable due to the lack of detailed data, mainly from Spiralia.

Results

Here we characterize the Pdu-Tcf gene, a Tcf/LEF orthologue and a component of Wnt/β-catenin pathway from Platynereis dumerilii, a spiralian, marine annelid worm. Pdu-Tcf undergoes extensive alternative splicing in the C-terminal region of the gene gene

SUBMITTER: Zidek R 

PROVIDER: S-EPMC5996498 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature