PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction.

ABSTRACT:

Background

Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve placental growth and development. We predicted that, if the upregulation of PAPP-A2 in pregnancy complications reflects a compensatory response, then deletion of Pappa2 in mice would exacerbate the effects of a gene deletion previously reported to impair placental development: deficiency of matrix metalloproteinase-9 (MMP9).

Methods

We crossed mice carrying deletions in Pappa2 and Mmp9 to produce pregnancies deficient in one, both, or neither of these genes. We m

SUBMITTER: Christians JK 

PROVIDER: S-EPMC5996520 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature