Predictors of atrial fibrillation in ibrutinib-treated CLL patients: a prospective study.

ABSTRACT:

Background

Ibrutinib is an oral irreversible inhibitor of Bruton's tyrosine kinase, indicated for the treatment of chronic lymphocytic leukaemia. The drug is generally well tolerated; however, not infrequent side effects are reported, with the major two being bleeding and ibrutinib-related atrial fibrillation. Atrial fibrillation pathogenesis in this setting is not completely clear, and no prospective studies have evaluated the impact of previous cardiologic history and baseline characteristics.

Methods

We prospectively performed cardiologic assessment in 43 CLL patients before starting ibrutinib therapy. Cardiologic workup included comorbidity collection and electrocardiographic and echocardiographic baseline evaluation.

Results

After a median observation of 8 months

SUBMITTER: Reda G 

PROVIDER: S-EPMC5996546 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature