Dynamic Hyaluronan drives liver endothelial cells towards angiogenesis.

ABSTRACT:

Background

Angiogenesis, the formation of new blood vessels from pre-existing vasculature is essential in a number of physiological processes such as embryonic development, wound healing as well as pathological conditions like, tumor growth and metastasis. Hyaluronic acid (HA), a high molecular weight polysaccharide, major component of extracellular matrix is known to associate with malignant phenotypes in melanomas and various other carcinomas. Hyaluronic acid binding protein 1 (HABP1) has been previously reported to trigger enhanced cellular proliferation in human liver cancer cells upon its over-expression. In the present study, we have identified the HA mediated cellular behaviour of liver endothelial cells during angiogenesis.

Methods

Endothelial cells have been isolate

SUBMITTER: Ghose S 

PROVIDER: S-EPMC5996548 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature