The Role of Forkhead Box Class O3A and SIRT1 Gene Variants in Early-Onset Psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory skin disorder, which is characterized by a heightened immunological response. Although the immunogenetics of this chronic inflammatory disorder is poorly understood, its expression is known to be dependent on proinflammatory cytokines. It is known that two distinct subtypes of chronic plaque psoriasis: Early-onset psoriasis (EOP) before the age of 40 years and late-onset psoriasis after the age of 40 years. Forkhead box class O3A (FOXO3A) is a transcription factor, which plays an important role in cell-cycle regulation, apoptosis, oxidative stress, and DNA repair. The silent information regulator (SIRT) is thought to have a role in skin disorders, including psoriasis, that are characterized by hyperproliferation and inflammation.

Ai

SUBMITTER: Pektas SD 

PROVIDER: S-EPMC5996633 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature