Hub Protein Controversy: Taking a Closer Look at Plant Stress Response Hubs.

ABSTRACT: Plant stress responses involve numerous changes at the molecular and cellular level and are regulated by highly complex signaling pathways. Studying protein-protein interactions (PPIs) and the resulting networks is therefore becoming increasingly important in understanding these responses. Crucial in PPI networks are the so-called hubs or hub proteins, commonly defined as the most highly connected central proteins in scale-free PPI networks. However, despite their importance, a growing amount of confusion and controversy seems to exist regarding hub protein identification, characterization and classification. In order to highlight these inconsistencies and stimulate further clarification, this review critically analyses the current knowledge on hub proteins in the plant interactome field.

SUBMITTER: Vandereyken K 

PROVIDER: S-EPMC5996676 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature