Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii.

ABSTRACT: Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps, especially those belonging to the resistance-nodulation-cell division (RND) superfamily of transporters. In this study, we analyzed functions and properties of RND efflux pumps in A. baumannii ATCC 17978. This strain is susceptible to antibiotics and does not contain mutations that are commonly selected upon exposure to high concentrations of antibiotics. We constructed derivatives of ATCC 17978 lacking chromosomally encoded RND pumps and complemented these strains by the plasmid-borne genes. We analyzed the substrate selectivities and efficiencies of the individual pumps in the context of native outer

SUBMITTER: Leus IV 

PROVIDER: S-EPMC5996695 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature