PCA3 rs544190G>A and prostate cancer risk in an eastern Chinese population.

ABSTRACT:

Background

The association of prostate cancer antigen 3 (PCA3) polymorphism (SNP, rs544190G>A) with metastatic prostate cancer in European descent has been reported. Our aim of the current study was to re-validate the effect of PCA3 polymorphism on prostate cancer risk in an Eastern Chinese population and then estimate possible genetic discrepancies among population.

Materials and methods

Taqman assay was employed to determine genotype of SNP rs544190 in 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancerfree controls. Simultaneously, odds ratios (OR) and 95% confidence intervals (95%CI) for risk relationship were calculated by logistic regression models.

Results

The statistically significant relationship between PCA3 rs544190G>A and higher prostate

SUBMITTER: Cao D 

PROVIDER: S-EPMC5996780 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature