APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.

ABSTRACT:

Objective

To examine the association of the APOE ε2ε4 genotype with incident Alzheimer disease (AD), mild cognitive impairment (MCI), cognitive decline, and AD pathology in older adults.

Methods

We used data from 2,151 older adults of European ancestry who were free of dementia at baseline and underwent structured annual clinical evaluation in a longitudinal study for incident AD and MCI, and cognitive decline. Postmortem examination in decedents documented pathologic AD and quantified β-amyloid and neurofibrillary tangles. Participants were stratified into 4 groups based on APOE genotyping: ε2ε4, ε4 (ε4ε4, ε4ε3), ε2 (ε2ε2, ε2ε3), with ε3ε3 carriers serving as the reference group. We used Cox proportional hazards models to examine the association of APOE

SUBMITTER: Oveisgharan S 

PROVIDER: S-EPMC5996834 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature