Soluble Mediators Produced by Pro-Resolving Macrophages Inhibit Angiogenesis.

ABSTRACT: Different subtypes of macrophages have been shown to participate in different stages of inflammation and tissue repair. In the late stage of tissue repair, the macrophages, following their engulfment of apoptotic neutrophils, acquire a new phenotype termed alternatively activated macrophages. These macrophages produce growth factors, such as vascular endothelial growth factor (VEGF), that facilitate the angiogenic response as part of tissue restoration. Then, in the later stages of tissue healing, capillary regression takes place. It is presently unknown whether macrophages play an antiangiogenic role in the final stages of tissue repair. Here, we examined whether soluble mediators secreted by pro-resolving CD11b^low macrophages (Mres) inhibit angiogenesis in the context of the r

SUBMITTER: Michaeli S 

PROVIDER: S-EPMC5996919 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature