Intravital Imaging of Tumor Cell Motility in the Tumor Microenvironment Context.

ABSTRACT: Cancer cell motility and invasion are key features of metastatic tumors. Both are highly linked to tumor microenvironmental parameters, such as collagen architecture or macrophage density. However, due to the genetic, epigenetic and microenvironmental heterogeneities, only a small portion of tumor cells in the primary tumor are motile and furthermore, only a small portion of those will metastasize. This creates a challenge in predicting metastatic fate of single cells based on the phenotype they exhibit in the primary tumor. To overcome this challenge, tumor cell subpopulations need to be monitored at several timescales, mapping their phenotype in primary tumor as well as their potential homing to the secondary tumor site. Additionally, to address the spatial heterogeneity of the tumor mic

SUBMITTER: Bayarmagnai B 

PROVIDER: S-EPMC5996994 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature