Kisspeptin and LH pulsatile temporal coupling in PCOS patients.

ABSTRACT: PURPOSE:To evaluate the temporal coupling between spontaneous kisspeptin and luteinizing hormone (LH) pulsatile releases in polycystic ovary syndrome (PCOS) patients. METHODS:We examined 71 patients diagnosed with PCOS. A 2 h pulsatility study was performed to evaluate serum kisspeptin and LH pulse frequency and concentration, sampled every 10 min; baseline follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), cortisol, 17-hydroksy-progesterone (17OHP), testosterone (T), free testosterone index (FTI, and insulin levels were also measured. Detect and Specific Concordance (SC) algorithms were used to evaluate the temporal coupling associations between spontaneous episodic secretion of kisspeptin and LH. RESULTS:All PCOS patients demonstrated LH and kisspeptin pulsatile secreti

SUBMITTER: Katulski K 

PROVIDER: S-EPMC5997113 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature