Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children.

ABSTRACT:

Importance

Because clinical features do not reliably distinguish bacterial from viral infection, many children worldwide receive unnecessary antibiotic treatment, while bacterial infection is missed in others.

Objective

To identify a blood RNA expression signature that distinguishes bacterial from viral infection in febrile children.

Design, setting, and participants

Febrile children presenting to participating hospitals in the United Kingdom, Spain, the Netherlands, and the United States between 2009-2013 were prospectively recruited, comprising a discovery group and validation group. Each group was classified after microbiological investigation as having definite bacterial infection, definite viral infection, or indeterminate infection. RNA expression signatures dis

SUBMITTER: Herberg JA 

PROVIDER: S-EPMC5997174 | biostudies-literature | 2016 Aug 23-30

REPOSITORIES: biostudies-literature