Multivalent Presentation of Peptide Targeting Groups Alters Polymer Biodistribution to Target Tissues.

ABSTRACT: Drug delivery to bone is challenging, whereby drug distribution is commonly <1% of injected dose, despite development of several bone-targeted drug delivery systems specific to hydroxyapatite. These bone-targeted drug delivery systems still suffer from poor target cell localization within bone, as at any given time overall bone volume is far greater than acutely remodeling bone volume, which harbors relevant cell targets (osteoclasts or osteoblasts). Thus, there exists a need to target bone-acting drugs specifically to sites of bone remodeling. To address this need, this study synthesized oligo(ethylene glycol) copolymers based on a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by osteoclasts during the bone resorption phase of bone remodelin

SUBMITTER: Newman MR 

PROVIDER: S-EPMC5997262 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature