Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics.

ABSTRACT: Success rates for catheter ablation of persistent atrial fibrillation patients are currently low; however, there is a subset of patients for whom electrical isolation of the pulmonary veins alone is a successful treatment strategy. It is difficult to identify these patients because there are a multitude of factors affecting arrhythmia susceptibility and maintenance, and the individual contributions of these factors are difficult to determine clinically. We hypothesised that the combination of pulmonary vein (PV) electrophysiology and atrial body fibrosis determine driver location and effectiveness of pulmonary vein isolation (PVI). We used bilayer biatrial computer models based on patient geometries to investigate the effects of PV properties and atrial fibrosis on arrhythmia inducibility,

SUBMITTER: Roney CH 

PROVIDER: S-EPMC5997352 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature