Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.

ABSTRACT: Circadian clocks, present in almost all cells of the body, are entrained to rhythmic changes in the environment (e.g. light/dark cycles). Genes responsible for this timekeeping are named core-clock genes, which through transcriptional feedback interactions mediated by transcription factor binding to Ebox/RRE/Dbox elements can generate oscillatory activity of their expression. By regulating the transcription of other clock-controlled genes (CCGs) circadian information is transmitted to tissue and organ levels. Recent studies have indicated that there is a considerable variability of clock-controlled gene expression between tissues both with respect to the circadian genes that are regulated and to their phase lags. In this work, a mathematical model was adapted to explore the dynamics of cor

SUBMITTER: Mavroudis PD 

PROVIDER: S-EPMC5997360 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature