Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury.

ABSTRACT:

Background

Myocardium irreversibly injured by ischemic stress must be efficiently repaired to maintain tissue integrity and contractile performance. Macrophages play critical roles in this process. These cells transform across a spectrum of phenotypes to accomplish diverse functions ranging from mediating the initial inflammatory responses that clear damaged tissue to subsequent reparative functions that help rebuild replacement tissue. Although macrophage transformation is crucial to myocardial repair, events governing this transformation are poorly understood.

Methods

Here, we set out to determine whether innate immune responses triggered by cytoplasmic DNA play a role.

Results

We report that ischemic myocardial injury, along with the resulting release of nucleic ac

SUBMITTER: Cao DJ 

PROVIDER: S-EPMC5997506 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature