Aspirin and clopidogrel high on-treatment platelet reactivity and genetic predictors in peripheral arterial disease.

ABSTRACT: OBJECTIVES:Our aims were to examine the prevalence and genetic predictors of aspirin and clopidogrel high on-treatment platelet reactivity (HoTPR), and associated adverse cardiovascular outcomes in patients with peripheral arterial disease (PAD). BACKGROUND:The association of aspirin and clopidogrel HoTPR with outcomes in PAD remains unclear. METHODS:This is a prospective cohort study of patients with angiographically documented PAD involving carotid and lower extremity arteries. Aspirin and clopidogrel HoTPR (using the VerifyNow Assay) and associated genetic predictors were compared to clinical outcomes. The primary end-point was a composite of major adverse cardiovascular events: all-cause mortality, myocardial infarction, stroke, target vessel revascularization (TVR) and limb-loss in pa

SUBMITTER: Yeo KK 

PROVIDER: S-EPMC5997520 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature