Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis.

ABSTRACT: Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography (CT) scan, histopathology and enzyme-linked immune sorbent assay (ELISA) were used to evaluate the effects o

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5997630 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature