Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review.

ABSTRACT:

Background

Schizophrenia is a complex illness in which genetic, environmental, and epigenetic components have been implicated. However, recently, psychiatric disorders appear to be related to a chronic inflammatory state, at the level of specific cerebral areas which have been found as well impaired and responsible for schizophrenia symptomatology. Hence, a role of inflammatory mediators and cytokines has been as well defined. Accordingly, the role of an acute inflammatory phase protein, the C-reactive protein (CRP) has been recently investigated.

Objective

The objective of the present study is to evaluate how PCR may represent a biomarker in schizophrenia, i.e. correlated with illness phases and/or clinical manifestation and/or psychopathological severity.

Methods

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SUBMITTER: Orsolini L 

PROVIDER: S-EPMC5997872 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature