The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Ghrh^-/- Mice Is Associated With an Important Splenic Atrophy and Relative B Lymphopenia.

ABSTRACT: A debate is still open about the precise control exerted by the somatotrope GH-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor 1 axis on the immune system. The objective of this study was to directly address this question through the use of Ghrh^-/- mice that exhibit a severe deficiency of their somatotrope axis. After control backcross studies and normalization for the reduced global weight of transgenic mice, no difference in weight and cellularity of the thymus was observed in Ghrh^-/- mice when compared with C57BL/6 wild-type (WT) control mice. Similarly, no significant change was observed in frequency and number of thymic T cell subsets. In the periphery, Ghrh^-/- mice exhibited an increase in T cell proportion

SUBMITTER: Bodart G 

PROVIDER: S-EPMC5997896 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature