Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin.

ABSTRACT: The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and metabolism contribute to several major human diseases including atherosclerosis and obesity. Sortilin associates with cardiovascular disease; however, the role of Sortilin in adipose tissue and lipid metabolism remains unclear. Here we show that in the low-density lipoprotein receptor-deficient (Ldlr^-/-) atherosclerosis model, Sortilin deficiency (Sort1^-/-) in female mice suppresses Niemann-Pick type C1-Like 1 (Npc1l1) mRNA levels, reduces body and white adipose tissue weight, and improves brown adipose tissue function partially via transcriptional downregulation of Krüppel-like factor 4 and Liver X receptor. Female Ldlr^-/-Sort

SUBMITTER: Hagita S 

PROVIDER: S-EPMC5998044 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature