UBXN3B positively regulates STING-mediated antiviral immune responses.

ABSTRACT: The ubiquitin regulatory X domain-containing proteins (UBXNs) are likely involved in diverse biological processes. Their physiological functions, however, remain largely unknown. Here we present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. We employ a tamoxifen-inducible Cre-LoxP approach to generate systemic Ubxn3b knockout in adult mice as the Ubxn3b-null mutation is embryonically lethal. Ubxn3b^-/-, like Sting^-/- mice, are highly susceptible to lethal herpes simplex virus 1 (HSV-1) and vesicular stomatitis virus (VSV) infection, which is correlated with deficient immune responses when compared to Ubxn3b^+/+ littermates. HSV-1 and STING agonist-induced immune responses are also reduced in several

SUBMITTER: Yang L 

PROVIDER: S-EPMC5998066 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature