Network biology discovers pathogen contact points in host protein-protein interactomes.

ABSTRACT: In all organisms, major biological processes are controlled by complex protein-protein interactions networks (interactomes), yet their structural complexity presents major analytical challenges. Here, we integrate a compendium of over 4300 phenotypes with Arabidopsis interactome (AI-1_MAIN). We show that nodes with high connectivity and betweenness are enriched and depleted in conditional and essential phenotypes, respectively. Such nodes are located in the innermost layers of AI-1_MAIN and are preferential targets of pathogen effectors. We extend these network-centric analyses to Cell Surface Interactome (CSI^LRR) and predict its 35 most influential nodes. To determine their biological relevance, we show that these proteins physically interact with pathogen e

SUBMITTER: Ahmed H 

PROVIDER: S-EPMC5998135 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature