Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function.

ABSTRACT:

Background

Emerging evidence suggests a possible role of the renin angiotensin system in the pathophysiologic process of Alzheimer's disease, of which angiotensin converting enzyme-1 (ACE-1) and angiotensin II (ANGII) are important proteins. Few studies evaluated associations between blood ACE-1 and none between ANGII levels, and cognition.

Objective

Our pilot study was aimed to examine associations between blood ACE-1 and ANG II levels and cognitive function in non-demented participants at baseline and over a 1-year period.

Methods

56 participants were included from the Brain Health Substudy of the Baltimore Experience Corps Study. Linear regression analysis, adjusting for confounders, was used to determine associations between baseline ACE-1 and ANGII, and baseline

SUBMITTER: Yasar S 

PROVIDER: S-EPMC5998658 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature