Generation and comparative genomics of synthetic dengue viruses.

ABSTRACT:

Background

Synthetic virology is an important multidisciplinary scientific field, with emerging applications in biotechnology and medicine, aiming at developing methods to generate and engineer synthetic viruses. In particular, many of the RNA viruses, including among others the Dengue and Zika, are widespread pathogens of significant importance to human health. The ability to design and synthesize such viruses may contribute to exploring novel approaches for developing vaccines and virus based therapies.

Results

Here we develop a full multidisciplinary pipeline for generation and analysis of synthetic RNA viruses and specifically apply it to Dengue virus serotype 2 (DENV-2). The major steps of the pipeline include comparative genomics of endogenous and synthetic viral strai

SUBMITTER: Goz E 

PROVIDER: S-EPMC5998877 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature