Functional enrichment analysis based on long noncoding RNA associations.

ABSTRACT: BACKGROUND:Differential gene expression analysis using RNA-seq data is a popular approach for discovering specific regulation mechanisms under certain environmental settings. Both gene ontology (GO) and KEGG pathway enrichment analysis are major processes for investigating gene groups that participate in common biological responses or possess related functions. However, traditional approaches based on differentially expressed genes only detect a few significant GO terms and pathways, which are frequently insufficient to explain all-inclusive gene regulation mechanisms. METHODS:Transcriptomes of survivin (birc5) gene knock-down experimental and wild-type control zebrafish embryos were sequenced and assembled, and a differential expression (DE) gene list was obtained for traditional function

SUBMITTER: Hung KS 

PROVIDER: S-EPMC5998891 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature