MEGADOCK-Web: an integrated database of high-throughput structure-based protein-protein interaction predictions.

ABSTRACT:

Background

Protein-protein interactions (PPIs) play several roles in living cells, and computational PPI prediction is a major focus of many researchers. The three-dimensional (3D) structure and binding surface are important for the design of PPI inhibitors. Therefore, rigid body protein-protein docking calculations for two protein structures are expected to allow elucidation of PPIs different from known complexes in terms of 3D structures because known PPI information is not explicitly required. We have developed rapid PPI prediction software based on protein-protein docking, called MEGADOCK. In order to fully utilize the benefits of computational PPI predictions, it is necessary to construct a comprehensive database to gather prediction results and their predicted 3D complex stru

SUBMITTER: Hayashi T 

PROVIDER: S-EPMC5998897 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature