Frontal Transcranial Direct Current Stimulation Induces Dopamine Release in the Ventral Striatum in Human.

ABSTRACT: A single transcranial direct current stimulation (tDCS) session applied over the dorsolateral prefrontal cortex (DLFPC) can be associated with procognitive effects. Furthermore, repeated DLPFC tDCS sessions are under investigation as a new therapeutic tool for a range of neuropsychiatric conditions. A possible mechanism explaining such beneficial effects is a modulation of meso-cortico-limbic dopamine transmission. We explored the spatial and temporal neurobiological effects of bifrontal tDCS on subcortical dopamine transmission during and immediately after the stimulation. In a double blind sham-controlled study, 32 healthy subjects randomly received a single session of either active (20 min, 2 mA; n = 14) or sham (n = 18) tDCS during a dynamic positron emission tomography scan using [11C

SUBMITTER: Fonteneau C 

PROVIDER: S-EPMC5998959 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature