Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation.

ABSTRACT: Evolutionary considerations suggest that the body has been optimized to perform at a high level in the food-deprived state when fatty acids and their ketone metabolites are a major fuel source for muscle cells. Because controlled food deprivation in laboratory animals and intermittent energy restriction in humans is a potent physiologic stimulus for ketosis, we designed a study to determine the impact of intermittent food deprivation during endurance training on performance and to elucidate the underlying cellular and molecular mechanisms. Male mice were randomly assigned to either ad libitum feeding or alternate-day food deprivation (ADF) groups, and half of the mice in each diet group were trained daily on a treadmill for 1 mo. A run to exhaustion endurance test performed at the end of t

SUBMITTER: Marosi K 

PROVIDER: S-EPMC5998977 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature