[¹⁸F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne-azide cycloaddition.

ABSTRACT: A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [¹⁸F]oxadibenzocyclooctyne ([¹⁸F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

SUBMITTER: Boudjemeline M 

PROVIDER: S-EPMC5999037 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature