Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression.

ABSTRACT:

Background

Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients.

Methods and findings

Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence. In total, 3

SUBMITTER: Mendoza-Pinto C 

PROVIDER: S-EPMC5999233 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature