Irreversible temperature gating in trpv1 sheds light on channel activation.

ABSTRACT: Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening.

SUBMITTER: Sanchez-Moreno A 

PROVIDER: S-EPMC5999395 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature